In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated vindesine resistance
H Arioka, K Nishio, Y Heike, S Abe, N Saijo - Journal of cancer research …, 1997 - Springer
Rhizoxin is an antineoplastic drug that inhibits tubulin polymerization. In this study, we
demonstrated that rhizoxin was approximately twice as active in vitro against a human small-
cell lung cancer cell line with non-P-glycoprotein-mediated resistance to vindesine,
H69/VDS, as against its parental line, H69. Tubulin polymerization in H69/VDS,
demonstrated by Western blot analysis, was inhibited markedly by rhizoxin compared with
that in H69, in a concentration-dependent manner. A drug-accumulation study showed that …
demonstrated that rhizoxin was approximately twice as active in vitro against a human small-
cell lung cancer cell line with non-P-glycoprotein-mediated resistance to vindesine,
H69/VDS, as against its parental line, H69. Tubulin polymerization in H69/VDS,
demonstrated by Western blot analysis, was inhibited markedly by rhizoxin compared with
that in H69, in a concentration-dependent manner. A drug-accumulation study showed that …
[引用][C] In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated vindesine resistance
有岡仁 - 1997 - ci.nii.ac.jp
CiNii 博士論文 - In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated
vindesine resistance … In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated
vindesine resistance リゾキシンによる,P糖蛋白質を介さないビンデシン耐性のin vitroおよびin
vivoでの克服 … In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated
vindesine resistance …
vindesine resistance … In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated
vindesine resistance リゾキシンによる,P糖蛋白質を介さないビンデシン耐性のin vitroおよびin
vivoでの克服 … In vitro and in vivo modulation by rhizoxin of non-P-glycoprotein-mediated
vindesine resistance …
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